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Cadherins and associated proteins.

M J Wheelock1, K A Knudsen

  • 1Department of Biology, University of Toledo, OH 43606.

In Vivo (Athens, Greece)
|September 1, 1991
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Summary
This summary is machine-generated.

Cadherins, cell adhesion proteins, bind to catenins, which link them to the cytoskeleton. This association occurs early in their development, regardless of cell type or organism.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cadherins are crucial calcium-dependent cell-cell adhesion glycoproteins.
  • They are essential for tissue development and maintenance in multicellular organisms.

Purpose of the Study:

  • To investigate the association between cadherins and catenins.
  • To determine if catenins link cadherins to the actin cytoskeleton.
  • To characterize the catenin repertoire across different cadherins, cell types, and organisms.

Main Methods:

  • Isolation of cadherins (E-, P-, and N-cadherin) and associated proteins.
  • Analysis of the catenin repertoire in different cellular contexts.

Main Results:

  • Three distinct cadherins associate with a conserved group of proteins called catenins.
  • The catenin repertoire is consistent within the same cell but varies between different cell types and organisms.
  • Catenin association with cadherins is independent of calcium-dependent conformation and precedes cell surface expression.

Conclusions:

  • Catenins serve as intermediaries, linking cadherins to the actin cytoskeleton.
  • The cadherin-catenin complex is fundamental to cell adhesion across diverse species.
  • The timing of catenin association suggests a critical role in early stages of cadherin complex formation.