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Updated: Jul 13, 2026

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
Safety and adverse effects associated with GLP-1 analogues
Jeffrey W Stephens1, Stephen C Bain
1Swansea University, Diabetes Research Group, The Medical School, Swansea, UK. J.W.Stephens@Swansea.ac.uk
Abstract:
The incretin mimetics are an emerging class of agents for the treatment of diabetes. So far, exenatide is licensed for use in the US and also became available in the UK in May 2007. Within development and Phase III trials, liraglutide may also be made available within the next 2 years. These agents enhance glucose-dependent insulin secretion and exhibit other antihyperglycaemic actions, which are of particular benefit to overweight patients with Type 2 diabetes. This article reviews the profile of adverse effects for these agents in relation to their current (exenatide) and anticipated (liraglutide) role in the management of Type 2 diabetes.
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