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Vascular mania: an old concept in danger of sclerosing? A clinical overview

C Wijeratne1, G S Malhi

  • 1School of Psychiatry, University of NSW, The Prince of Wales Hospital, Sydney, New South Wales, Australia. c.wijeratne@bigpond.com

Acta Psychiatrica Scandinavica. Supplementum
|October 19, 2007
PubMed

Insights

Evidence suggests a link between vascular disease and mania. Further research is needed to confirm if vascular mania is a distinct subtype, potentially with late-onset characteristics.

Area of Science:

  • Neurology
  • Psychiatry
  • Vascular Medicine

Background:

  • The relationship between vascular disease and mania is not well-defined.
  • Existing literature includes case reports and varied terminology, hindering clear understanding.

Purpose of the Study:

  • To review evidence associating vascular disease with mania.
  • To evaluate proposed diagnostic criteria for this association.

Main Methods:

  • Literature search of MEDLINE, PsychInfo, and EMBASE (1996-2006).
  • Review of articles due to limited data, precluding systematic evidence level application.

Main Results:

  • A tentative association exists between mania and vascular risk factors/cerebrovascular disease.
  • The term "vascular mania" is proposed for clinical utility, despite implying causality.
  • Proposed criteria for late-onset mania (age 50+) show non-specific neuroimaging and neuropsychological changes.

Conclusions:

  • Further studies are required to establish vascular mania as a distinct subtype with late-onset features.
  • An alternative framework for conceptualizing vascular mania is presented.
Abstract

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