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Related Experiment Videos

Psilocybin-induced stimulus control in the rat.

J C Winter1, K C Rice, D J Amorosi

  • 1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA. jcwinter@buffalo.edu

Pharmacology, Biochemistry, and Behavior
|August 11, 2007
PubMed
Summary
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Psilocybin

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychopharmacology

Background:

  • Psilocybin is a psychedelic compound, but the specific receptors it acts on for its effects are not fully understood.
  • Research into the pharmacological basis of psilocybin's discriminative stimulus properties in animal models is limited.

Purpose of the Study:

  • To investigate the role of specific neurotransmitter receptors in mediating the stimulus effects of psilocybin in rats.
  • To determine the contribution of serotonin 5-HT(2A) and dopamine D(2) receptors to psilocybin's discriminative stimulus.

Main Methods:

  • Rats were trained to discriminate psilocybin from a saline vehicle.
  • The effects of selective receptor antagonists (M100907, WAY-100635, remoxipride) on psilocybin discrimination were assessed.

Related Experiment Videos

  • Generalization tests with other psychoactive compounds were conducted.

    • Main Results:

    • The 5-HT(2A) receptor antagonist M100907 partially blocked psilocybin's effects.
    • The 5-HT(1A/7) antagonist WAY-100635 and the D(2) antagonist remoxipride did not significantly antagonize psilocybin.
    • Psilocybin generalized to DOM, LSD, psilocin, and DMT (with WAY-100635), but not PCP. LSD and MDMA partially generalized to psilocybin, blocked by M100907.

    Conclusions:

    • Serotonin 5-HT(2A) receptor activity is a significant, though not sole, component of psilocybin's discriminative stimulus.
    • Unlike some related hallucinogens, psilocybin's stimulus control does not appear to involve 5-HT(1A) receptor agonism.