Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 1, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized mice.

J C Winter1, D J Amorosi, Kenner C Rice

  • 1Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA. jcwinter@buffalo.edu

Pharmacology, Biochemistry, and Behavior
|June 1, 2011
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioengineered miR-148a-3p suppresses glycolysis and amino acid homeostasis in hepatocellular carcinoma cells by regulating multiple solute carrier transporters.

Liver research (Beijing, China)·2026
Same author

Toxicological Evaluation of the Roots of <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng.

Food science & nutrition·2026
Same author

Metabolomics-based predictive biomarker discovery for thiopurine response in Crohn disease: Plasma histidine as a promising biomarker.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Design, expression, purification, and application of novel recombinant miR-491 molecules to define the biogenesis and function of miR-491-3p versus -5p in posttranscriptional regulation of UDP-glucuronosyltransferase 1A1.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Efficiency and safety of five different agents for <i>in vivo</i> delivery of novel bioengineered RNAi molecules.

Frontiers in molecular biosciences·2026
Same author

Comparative effectiveness of 7 major human let-7-5p isoforms to modulate target gene expression in liver cells.

Drug metabolism and disposition: the biological fate of chemicals·2026

This study found that genetically modified mice (Tg-CYP2D6) and wild-type mice acquired 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) stimulus control similarly. Harmaline enhanced 5-MeO-DMT

Area of Science:

  • Pharmacology
  • Neuroscience
  • Genetics

Background:

  • Previous studies indicated Tg-CYP2D6 mice exhibit altered bufotenine metabolism compared to wild-type mice.
  • 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and bufotenine are tryptamines with distinct pharmacological profiles.
  • Harmaline is a known MAO inhibitor that can affect tryptamine metabolism and signaling.

Purpose of the Study:

  • To investigate the acquisition of 5-MeO-DMT-induced stimulus control in wild-type and Tg-CYP2D6 mice.
  • To compare the behavioral effects of bufotenine and acetylbufotenine in these mouse models.
  • To determine the modulatory effect of harmaline on 5-MeO-DMT stimulus control.

Main Methods:

  • Establishing 5-MeO-DMT stimulus control in wild-type and Tg-CYP2D6 mice using operant conditioning.

More Related Videos

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

Related Experiment Videos

Last Updated: Jun 1, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
10:28

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

  • Testing the stimulus generalization properties of bufotenine and acetylbufotenine.
  • Administering harmaline alone and in combination with 5-MeO-DMT to assess its modulatory effects.

    • Main Results:

    • Both wild-type and Tg-CYP2D6 mice acquired 5-MeO-DMT stimulus control at similar rates.
    • Bufotenine did not elicit 5-MeO-DMT-appropriate responding, while acetylbufotenine produced intermediate responding.
    • Harmaline significantly enhanced 5-MeO-DMT-appropriate responding in both mouse groups, and harmaline alone induced such responding in Tg-CYP2D6 mice.

    Conclusions:

    • Wild-type and Tg-CYP2D6 mice exhibit comparable acquisition of 5-MeO-DMT stimulus control.
    • Bufotenine and acetylbufotenine do not fully substitute for 5-MeO-DMT in stimulus control paradigms.
    • Harmaline potentiates the stimulus effects of 5-MeO-DMT in both wild-type and Tg-CYP2D6 mice, suggesting a role in modulating tryptamine signaling.