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Nitroxyl (HNO) therapeutics: exposure control and target engagement
1Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, c/Francisco Tomás y Valiente, 7, Campus de Excelencia de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.
Abstract:
Nitroxyl (HNO) donors enhance cardiac contraction and relaxation. However, systemic administration of these donors provides limited control over local HNO exposure or interaction with the target. This forum discusses recent approaches and challenges to control HNO generation, reshape exposure, and assess target engagement, evaluating mechanisms, maturity, constraints, and therapeutic fit.
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