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Updated: Jul 13, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Amphetamine-associated ischemic stroke: clinical presentation and proposed pathogenesis.
Deidre Anne De Silva1, Meng Cheong Wong, Moi Pin Lee
1Singapore General Hospital, National Neuroscience Institute, Singapore. gnrdsd@sgh.com.sg <gnrdsd@sgh.com.sg>
Summary
Amphetamine use can cause ischemic stroke, a serious condition affecting the brain. This case report highlights amphetamine-induced cerebral artery stenosis and its resolution over time.
Area of Science:
- Neurology
- Vascular Neurology
- Toxicology
Background:
- Amphetamine use is associated with various cardiovascular complications.
- Cerebral infarction is a rare but severe consequence of stimulant drug abuse.
Observation:
- A young female presented with acute ischemic stroke in the left middle cerebral artery territory following amphetamine use.
- Serial angiography and transcranial Doppler studies were performed.
Findings:
- The patient exhibited stenosis of the middle cerebral artery, which resolved completely within 3 months.
- Angiography showed a "beaded" appearance, suggesting vasculitis or vasospasm.
- Microembolic signals indicated acute thrombosis and distal embolism.
Implications:
- This case suggests amphetamine-induced vasculitis or vasospasm as a potential cause of ischemic stroke.
- Early diagnosis and management are crucial for patients with suspected drug-induced cerebrovascular events.
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