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Updated: Jul 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-year prospective

Yael Leitner1, Aviva Fattal-Valevski, Ronny Geva

  • 1Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Israel.

Journal of Child Neurology
|August 11, 2007
PubMed

Insights

Children with intrauterine growth retardation face lasting neurodevelopmental and cognitive challenges, impacting school success. Early growth and the Cephalization Index predict outcomes.

Area of Science:

  • Pediatric Neurodevelopment
  • Growth Disorders
  • Cognitive Science

Background:

  • Intrauterine growth retardation (IUGR) affects fetal development, potentially leading to long-term health issues.
  • Understanding the specific neurodevelopmental and cognitive sequelae of IUGR is crucial for early intervention.
  • Predictors of neurodevelopmental outcomes in IUGR children require further investigation.

Purpose of the Study:

  • To characterize the neurodevelopmental and cognitive difficulties in children with IUGR from birth to 9-10 years.
  • To identify clinical predictors of these neurodevelopmental and cognitive difficulties.
  • To compare outcomes between children with IUGR and appropriate-for-gestational-age controls.

Main Methods:

  • Prospective follow-up of 123 children with IUGR from birth to 9-10 years.
  • Collection of perinatal biometric data and risk factors.
  • Neurodevelopmental, cognitive, and school achievement assessments at 9-10 years, compared to 63 controls.

Main Results:

  • Children with IUGR showed significant deficits in growth, neurodevelopmental scores, intelligence quotient (IQ), and school achievements compared to controls (P < .001).
  • A specific neurocognitive difficulty profile was observed in IUGR children, correlating with lower school achievements.
  • The Cephalization Index was the strongest perinatal predictor of neurodevelopment and IQ (P < .001).

Conclusions:

  • Children with IUGR exhibit distinct neurodevelopmental and cognitive challenges impacting academic performance.
  • The Cephalization Index is a key perinatal predictor for neurodevelopmental outcomes in IUGR.
  • Somatic catch-up growth is associated with improved outcomes at school age.

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