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Cardiac angiosarcoma--a review.

Antonio Murinello1, Paula Mendonça, Ana Abreu

  • 1Serviços de Medicina I e de Dermatologia do Hospital Curry Cabral, Lisboa, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|August 19, 2007
PubMed
Summary
This summary is machine-generated.

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Cardiac angiosarcoma (AS) is a rare tumor often diagnosed late due to vague symptoms. This review highlights diagnostic challenges and poor prognosis despite aggressive treatments for this aggressive heart cancer.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Cardiac angiosarcoma (AS) is an exceptionally rare malignancy.
  • Diagnosis is often delayed due to non-specific symptoms, complicating early intervention.

Observation:

  • A case of right atrial angiosarcoma presented with superior vena cava syndrome, urticaria, and polyarthralgias.
  • Clinical manifestations included blood flow obstruction, valve dysfunction, arrhythmias, and embolic phenomena.

Findings:

  • Imaging and histopathology are crucial for diagnosis, with cytogenetic analysis offering further insights.
  • Surgical resection is challenging, often incomplete, with frequent metastases at diagnosis, leading to a poor prognosis.

Implications:

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  • Current treatments including chemotherapy, radiotherapy, and heart transplantation show limited efficacy in improving survival.
  • The association of urticaria with malignancy, though rare, warrants consideration in undiagnosed cases.