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Updated: Jul 13, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prognostic significance of platelet-derived growth factor-BB expression in human esophageal squamous cell carcinomas
Sohei Matsumoto1, Yukishige Yamada, Michihiro Narikiyo
1Department of Surgery, Nara Medical University School of Medicine, Nara, Japan. msohei@naramed-u.ac.jp
Background:
Cancer metastases are commonly found in the lymphatic system and tumor lymphangiogenesis requires the interplay of several growth factors. The expression of platelet-derived growth factor (PDGF)-BB and vascular endothelial growth factor (VEGF)-C in esophageal cancer was investigated to define their clinicopathological significance.
Materials And Methods:
Using immunohistochemistry, the expression of PDGF-BB and VEGF-C was examined, along with lymphatic vessel density (LVD) in 53 patients with esophageal cancer.
Results:
PDGF-BB and VEGF-C expression was positive in 31 cases (58.5%) and 38 cases (71.7%), respectively, and expression correlated with lymph node metastasis and lymphatic invasion. Furthermore, PDGF-BB expression correlated with the depth of tumor invasion and the size of the tumor, and PDGF-BB-positive patients had a significantly poorer prognosis than PDGF-BB-negative patients. The LVD in positive PDGF-BB or VEGF-C tumors was higher than in negative tumors.
Conclusion:
PDGF-BB may play a pivotal role in lymphangiogenesis and tumor growth in esophageal cancer.
