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Updated: Jul 13, 2026
04:37
A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Infection associated with orthopaedic fixation devices].
Philippe Boisrenoult1, Philippe Beaufils
1Service d'orthopédie-traumatologie, hôpital André-Mignot, 78150 Le Chesnay. pboisrenoult@ch-versailles.fr
La Revue Du Praticien
|August 19, 2007
Summary
Infections from orthopedic implants require careful management, avoiding antibiotics before cultures. Treatment focuses on fracture healing and preventing chronic osteomyelitis, often involving implant removal and tailored antibiotic therapy.
Area of Science:
- Orthopaedic surgery
- Infectious disease
- Microbiology
Context:
- Orthopaedic fixation devices are prone to infection, diagnosed via clinical, radiological, and microbiological methods.
- Pre-operative antimicrobial therapy can hinder accurate diagnosis; tissue sampling for culture is crucial before treatment initiation.
Purpose:
- To outline optimal management strategies for infections associated with orthopaedic fixation devices.
- To emphasize the importance of microbiological diagnosis and pathogen-specific antimicrobial susceptibility testing.
Summary:
- Infections are suspected clinically and radiologically, confirmed by microbiology. Avoid antibiotics before sampling. Goals are fracture consolidation and chronic osteomyelitis preservation.
- Acute, stable implant infections may allow retention with long-term antibiotics. Otherwise, remove the implant, use an external fixator, and consider tissue reconstruction.
- Administer pathogen-directed, susceptibility-based antimicrobial treatment for 6-12 weeks. Prognosis is generally good, with potential for late recurrences.
Impact:
- Informed clinical decision-making for managing orthopaedic implant infections.
- Improved patient outcomes through timely and appropriate treatment protocols.
- Reduced risk of chronic osteomyelitis and implant failure.
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