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Updated: Jul 13, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Increased interferon alpha receptor 2 mRNA levels is associated with renal cell carcinoma metastasis

Takao Kamai1, Yoshiaki Yanai, Kyoko Arai

  • 1Department of Urology, Dokkyo Medical University, Tochigi, Japan. kamait@dokkyomed.ac.jp

BMC Cancer
|August 19, 2007
PubMed
Abstract

Insights

Interferon-alpha receptor 2 (IFNAR2) expression in renal cell carcinoma (RCC) correlates with tumor progression and poor patient survival. High IFNAR2 levels indicate a worse prognosis and reduced response to interferon-alpha immunotherapy.

Area of Science:

  • Oncology
  • Immunotherapy
  • Molecular Biology

Background:

  • Interferon-alpha (IFN-alpha) is a key immunotherapy for renal cell carcinoma (RCC).
  • The Interferon-alpha receptor (IFNAR) mediates IFN-alpha signaling.
  • The specific role of IFNAR in RCC progression remained unclear.

Purpose of the Study:

  • To investigate the role of IFNAR in the progression of renal cell carcinoma (RCC).
  • To correlate IFNAR expression with clinical and pathological features of RCC.
  • To assess the predictive value of IFNAR expression for treatment response and patient survival.

Main Methods:

  • Quantified IFNAR mRNA and protein expression in 103 RCC patient samples using RT-PCR and Western blotting.
  • Analyzed the correlation between IFNAR expression levels (T/N ratio) and clinicopathological factors.
  • Performed multivariate analysis to determine the prognostic significance of IFNAR2 expression.

Main Results:

  • A high tumor-to-non-tumor (T/N) ratio of IFNAR2 mRNA correlated with poor differentiation, local invasion, and metastasis.
  • High IFNAR2 T/N ratio predicted shortened overall survival and disease-free survival in RCC patients.
  • Elevated IFNAR2 T/N ratio was associated with poorer response to IFN-alpha therapy.
  • Higher IFNAR2c protein expression was observed in primary tumors of patients with distant metastasis.

Conclusions:

  • IFNAR2 expression is significantly associated with the progression of renal cell carcinoma (RCC).
  • IFNAR2 serves as a potential biomarker for predicting prognosis and treatment response in RCC.
  • Targeting IFNAR2 may offer new therapeutic strategies for advanced RCC.

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