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Related Concept Videos

Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

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Related Experiment Video

Updated: Jul 13, 2026

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

Studies on integrins in the nervous system.

Sumiko Denda1, Louis F Reichardt

  • 1Shiseido Research Center 2, Kanazawa-ku, Yokohama, Japan.

Methods in Enzymology
|August 19, 2007
PubMed
Summary

Integrins play crucial roles in neural development and function. This study details methods for analyzing integrin involvement in neuronal responses to the extracellular matrix, aiding in understanding neurological diseases.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Integrins are widely expressed in the nervous system, influencing neural development and function.
  • Integrins are implicated in neurodegenerative diseases, brain tumors, and nervous system injury.
  • Integrin antagonists are being explored as therapeutics for neurological disorders.

Purpose of the Study:

  • To describe laboratory methods for characterizing neuronal responses to extracellular matrix proteins.
  • To outline procedures for assessing integrin roles in neuronal cell attachment and differentiation.

Main Methods:

  • Characterization of neuronal responses to extracellular matrix (ECM) proteins.
  • Assessment of integrin involvement in neuronal cell attachment.
  • Evaluation of integrin roles in neuronal differentiation.

More Related Videos

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Studying the Integration of Adult-born Neurons
09:00

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

Related Experiment Videos

Last Updated: Jul 13, 2026

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Studying the Integration of Adult-born Neurons
09:00

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

Main Results:

  • Detailed methods for analyzing integrin-mediated neuronal functions.
  • Established procedures for studying neuronal development and injury.

Conclusions:

  • The described methods facilitate the study of integrin functions in the nervous system.
  • Understanding integrin roles is vital for developing treatments for neurological conditions.