Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The case against calcium-based phosphate binders.

Sharon M Moe1, Glenn M Chertow

  • 1Department of Medicine, Indiana University School of Medicine, 1001 W. 10th Street, OPW 526, Indianapolis, IN 46260, USA. smoe@iupui.edu

Clinical Journal of the American Society of Nephrology : CJASN
|August 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rationale and protocol of the Dapagliflozin And Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2020
Same author

Screening Rates for Primary Aldosteronism in Resistant Hypertension: A Cohort Study.

Hypertension (Dallas, Tex. : 1979)·2020
Same author

The ongoing search for a robust clinical prediction model of ICU AKI.

Clinical nephrology·2020
Same author

Central venous pressure and the risk of diuretic-associated acute kidney injury in patients after cardiac surgery.

American heart journal·2020
Same author

Effect of Intensive vs Standard Blood Pressure Treatment Upon Erectile Function in Hypertensive Men: Findings From the Systolic Blood Pressure Intervention Trial.

The journal of sexual medicine·2019
Same author

Safety-Net Care for Maintenance Dialysis in the United States.

Journal of the American Society of Nephrology : JASN·2019
Same journal

A Patient's Perspective on Arteriovenous Fistula Care and Far-Infrared Radiation Arteriovenous Fistula Therapy.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

A Beacon of Hope: Pegcetacoplan for Adolescents with C3 Glomerulopathy or Primary Immune Complex Membranoproliferative GN.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

Sequential Biomarker Testing in Kidney Transplant Surveillance: How Far Does One Step at a Time Take Us?

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

The Predicting Risk of Cardiovascular Disease Event Equation Meets CKD.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

Muscle Cramp Rate, Severity and Burden in Maintenance Hemodialysis Patients: A Yearlong Multicenter Quality Improvement Initiative.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same journal

From Risk Determinants to Clinical Action: Understanding and Implementing the Cardiovascular Kidney Metabolic Syndrome Framework.

Clinical journal of the American Society of Nephrology : CJASN·2026
See all related articles

Calcium-based phosphate binders may worsen vascular calcification in dialysis patients. Avoiding these binders is recommended due to risks associated with mineral metabolism disturbances and lack of safe dosage monitoring.

Area of Science:

  • Nephrology
  • Mineral Metabolism
  • Cardiovascular Health

Background:

  • Mineral metabolism disturbances are common in chronic kidney disease (CKD) patients, leading to significant morbidity and mortality.
  • Current treatments for these disturbances can also be associated with adverse effects.
  • Vascular calcification is a serious complication in CKD patients.

Purpose of the Study:

  • To evaluate the association between calcium-based phosphate binders and vascular calcification in CKD patients.
  • To compare the effects of calcium-based binders versus non-calcium-based binders on vascular calcification.
  • To highlight the limitations in monitoring calcium balance and safe dosing.

Main Methods:

  • Review of prospective, randomized trials.

Related Experiment Videos

  • Analysis of biologic plausibility regarding hyperphosphatemia and calcium administration.
  • Assessment of current diagnostic limitations for calcium balance.

    • Main Results:

    • Evidence suggests calcium-based phosphate binders contribute to progressive coronary artery and aorta calcification.
    • Non-calcium-containing binders, like sevelamer, may offer a safer alternative.
    • Serum calcium levels do not accurately reflect calcium balance, and no bedside test exists to determine safe calcium salt dosage.

    Conclusions:

    • Calcium-based phosphate binders should be avoided in most dialysis patients.
    • Hyperphosphatemia and excess calcium intake can accelerate vascular calcification.
    • Alternative phosphate binders are recommended to mitigate risks in CKD patients.