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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Calcium-based phosphate binders are appropriate in chronic renal failure
1Department of Medicine, Renal Disease Division, Downstate Medical Center, Brooklyn, NY 11203, USA. elifriedmn@aol.com
Clinical Journal of the American Society of Nephrology : CJASN
|August 21, 2007
Summary
Calcium-based phosphate binders may be safe and effective for chronic renal failure patients, despite concerns about cardiac calcification. Cost-effectiveness and trial flaws question the widespread shift to sevelamer.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Pharmacology
Background:
- Concerns exist regarding calcium-based phosphate binders (calcium acetate, calcium carbonate) and cardiac calcification in chronic renal failure patients.
- Sevelamer, a non-calcium-based binder, is proposed as a safer alternative, but this review questions the evidence.
Discussion:
- The study critically examines clinical trials favoring sevelamer, citing potential flaws and weak evidence linking oral calcium to vascular calcification.
- It highlights existing clinical trial data supporting the safety and efficacy of calcium-based phosphate binders.
- The significant cost difference between calcium-based binders and sevelamer is a key consideration.
Key Insights:
- Evidence supporting sevelamer's superiority over calcium-based binders may be flawed.
- Calcium-based phosphate binders demonstrate safety and efficacy in managing hyperphosphatemia.
- Cost-effectiveness favors traditional calcium-based phosphate binders.
Outlook:
- Ongoing evaluation of established and novel phosphate binders necessitates an open-minded approach.
- Clinicians must stay informed about emerging literature to optimize hyperphosphatemia management in renal failure.
- Further research is needed to definitively compare long-term outcomes and safety profiles.
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