Related Experiment Video

Updated: Jul 13, 2026

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis

Niki E Tsesmeli1, Kleanthis E Giannoulis, Christos G Savopoulos

  • 11st Propedeutic Medical Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, Greece. tsesn@med.auth.gr

European Journal of Gastroenterology & Hepatology
|August 19, 2007
PubMed

Insights

This case study highlights metronidazole-induced acute pancreatitis in an ulcerative colitis patient. Prompt withdrawal of metronidazole led to recovery, emphasizing medication-induced pancreatitis awareness in inflammatory bowel disease management.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Inflammatory bowel disease (IBD) management often involves multiple medications.
  • Ulcerative colitis (UC) patients may experience drug-related complications.
  • Accurate attribution of adverse events is crucial for treatment optimization.

Observation:

  • A 31-year-old male with UC presented with abdominal pain and nausea.
  • The patient had recently been administered metronidazole for a UC relapse.
  • Investigations confirmed acute pancreatitis.

Findings:

  • Acute pancreatitis was strongly suspected to be caused by metronidazole.
  • Discontinuation of metronidazole and mesalamine led to complete recovery.
  • Reintroduction of mesalamine did not result in pancreatitis recurrence.

Implications:

  • Metronidazole should be considered a potential cause of acute pancreatitis in IBD patients.
  • Differentiating drug-induced pancreatitis is vital for managing IBD.
  • This case underscores the importance of vigilant medication review in IBD care.

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...