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Relation between serum calcium, phosphate, parathyroid hormone and 'nondipper' circadian blood pressure variability

Mehmet Kanbay1, Bunyamin Isik, Ali Akcay

  • 1Department of Internal Medicine, Section of Nephrology, Fatih University Faculty of Medicine, Ankara, Turkey. mkanbay@fatih.edu.tr

American Journal of Nephrology
|August 19, 2007
PubMed

Insights

Higher phosphate and parathyroid hormone (PTH) levels are linked to nondipper hypertension in patients with normal kidney function. This suggests a connection between mineral metabolism and abnormal blood pressure patterns, even without kidney disease.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Abnormal circadian blood pressure is linked to bone and mineral metabolism issues in renal disease.
  • This association has not been previously reported in hypertensive patients with normal renal function.

Purpose of the Study:

  • To investigate the association between serum phosphate, calcium, parathyroid hormone (PTH), and the calcium x phosphate (Ca x P) product with nondipper hypertension.
  • To evaluate these factors in hypertensive patients with normal renal function and no PTH disorders.

Main Methods:

  • 190 hypertensive patients with normal phosphate and PTH levels were enrolled.
  • Inclusion criteria included a glomerular filtration rate (GFR) >60 ml/min and no history of calcium, phosphate, vitamin D medication, or hyperparathyroidism.

Main Results:

  • Nondipper patients (60%) exhibited higher phosphate, Ca x P product, and PTH levels compared to dipper patients (40%).
  • Parathyroid hormone (PTH) and phosphate were identified as independent predictors of nondipper hypertension.

Conclusions:

  • A relationship exists between elevated phosphate, PTH, and Ca x P product and the risk of nondipping in hypertensive individuals.
  • This finding highlights the importance of mineral metabolism in the development of abnormal circadian blood pressure profiles, even in the absence of renal disease.
Abstract

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