Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defenses Against Pathogens and Herbivores02:26

Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reconstruction from multi-planar MRI with foundation models for uterine fibroid analysis.

NPJ digital medicine·2026
Same author

Lignanamides, alkaloids, and other constituents from stems of <i>Tinospora crispa</i>.

Natural product research·2026
Same author

Brain Magnetic Resonance Elastography Experiments With an Electromagnetic Actuator.

Current protocols·2026
Same author

Magnetically Guided Microrobots for Targeted Drug Delivery.

Advanced healthcare materials·2026
Same author

Multiscale measurement of brain tissue and cell biomechanics using a mouse model.

Biophysics reports·2026
Same author

Lanostane-type triterpenoids from the fungus <i>Inonotus obliquus</i>.

Natural product research·2025

Related Experiment Video

Updated: Jul 13, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Terpenoids and flavonoids from Laggera pterodonta.

Guang-Zhong Yang1, Yun-Fang Li, Xin Yu

  • 1Institute of National Medicine, South-Central University for Nationalities, Wuhan 430074, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|August 21, 2007
PubMed
Summary

This study identified eleven chemical compounds from Laggera pterodonta aerial parts, including a new monoterpene glucoside. Pterodontic acid and pterodontiol showed moderate antibacterial activity against several bacterial strains.

Related Experiment Videos

Last Updated: Jul 13, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Laggera pterodonta (DC.) Benth. is a plant species with potential medicinal properties.
  • Understanding its chemical composition is crucial for exploring its therapeutic applications.

Purpose of the Study:

  • To isolate and identify the chemical constituents from the aerial parts of Laggera pterodonta.
  • To evaluate the antibacterial activity of the isolated compounds.

Main Methods:

  • Air-dried aerial parts of L. pterodonta were extracted using boiling water.
  • Silica gel column chromatography and recrystallization were employed for purification.
  • Compound identification was performed using spectroscopic methods.
  • Antibacterial activity was assessed using the paper disc diffusion method.

Main Results:

  • Eleven compounds were isolated and identified: 6-O-beta-D-glucopyranosyl-carvotanacetone (1), pterodontic acid (2), 1beta-hydroxy pterondontic acid (3), pterodontoside A (4), pterodontiol (5), pterodontriol B (6), 5-hydroxy-3,4', 6,7-tetramethoxyflavone (7), artemitin (8), chrysosplenetin B (9), quercetin (10), and beta-sitosterol (11).
  • Compound 1 is a novel monoterpene glucoside.
  • Quercetin (10) and beta-sitosterol (11) were isolated from this plant for the first time.
  • Pterodontic acid (2) and pterodontiol (5) exhibited moderate activity against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei, and Bacillus circulans.
  • No activity was observed against Escherichia coli for compounds 2 and 5.

Conclusions:

  • The phytochemical investigation of Laggera pterodonta yielded eleven compounds, including a new monoterpene glucoside.
  • Pterodontic acid and pterodontiol possess notable antibacterial properties against specific Gram-positive and Gram-negative bacteria.
  • The findings contribute to the chemotaxonomic understanding of Laggera species and suggest potential for developing new antibacterial agents.