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Updated: Jul 13, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
The effect of neurodegenerative diseases on the subventricular zone
Maurice A Curtis1, Richard L M Faull, Peter S Eriksson
1Institute of Neuroscience and Physiology at Sahlgrenska Academy, Medicinaregat 11, Box 432, s-40530 Göteborg, Sweden. maurice.curtis@neuro.gu.se
Abstract:
During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
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