Related Experiment Video

Updated: Jul 13, 2026

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
09:46

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells

Published on: January 20, 2023

Growing a living blood vessel: insights for the second hundred years

Luke P Brewster1, Dominick Bufallino, Areck Ucuzian

  • 1Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.

Biomaterials
|August 21, 2007
PubMed

Insights

Cardiovascular disease is a global epidemic, driving demand for vascular procedures. Biomedical engineering innovations in prosthetic grafts and tissue-engineered vessels aim to enhance treatment durability and patient outcomes.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Regenerative Medicine

Background:

  • Cardiovascular disease (CVD) is the leading global cause of mortality.
  • The increasing prevalence of CVD necessitates more frequent vascular interventions.
  • Current prosthetic grafts have limitations in long-term efficacy.

Purpose of the Study:

  • To explore biomedical engineering strategies for improving vascular interventions.
  • To investigate advancements in prosthetic graft technology.
  • To assess the potential of tissue-engineered blood vessels for clinical use.

Main Methods:

  • Review of current biomedical engineering approaches in vascular graft development.
  • Analysis of innovations in prosthetic graft design and materials.
  • Evaluation of tissue engineering techniques for blood vessel creation.

Main Results:

  • Biomedical engineering offers promising avenues for enhancing prosthetic graft performance.
  • Development of novel materials and designs can improve graft durability.
  • Tissue-engineered vascular grafts show potential for clinical application in treating cardiovascular disease.

Conclusions:

  • Biomedical engineering innovations are crucial for improving long-term outcomes of vascular procedures.
  • Advancements in prosthetic grafts and tissue engineering hold significant promise for patients with cardiovascular disease.

More Related Videos

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor11:22

Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor

Published on: June 14, 2011

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Anatomy of Blood Vessels01:20

Anatomy of Blood Vessels

The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Overview of Blood Vessels01:14

Overview of Blood Vessels

The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...