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Basic fibroblast growth factor enema improves experimental colitis in rats.

Tetsu Kojima1, Toshiahi Watanabe, Keisuke Hata

  • 1Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Japan. kojimat-tky@umin.ac.jp

Hepato-Gastroenterology
|August 22, 2007
PubMed
Summary

Basic fibroblast growth factor (bFGF) enema shows promise for treating inflammatory bowel disease (IBD). This study found bFGF significantly improved clinical and histological scores in a rat colitis model, suggesting it as a safe and effective novel therapy.

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Area of Science:

  • Gastroenterology
  • Regenerative Medicine
  • Pharmacology

Background:

  • Growth factors play a role in gastrointestinal mucosal repair.
  • Basic fibroblast growth factor (bFGF) is known to aid wound healing.
  • The therapeutic role of bFGF in inflammatory bowel disease (IBD) requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of intracolonic bFGF administration in an experimental rat model of colitis.
  • To assess the impact of bFGF on both clinical symptoms and histological mucosal repair.
  • To determine the safety profile of bFGF in the context of IBD treatment.

Main Methods:

  • Acute colitis was induced in rats using 5% dextran sulfate sodium (DSS) for one week.
  • Rats received daily enemas of recombinant human bFGF (400 microg/kg/day) or vehicle from day 1 to day 7.

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  • Clinical scores (stool consistency, weight loss, rectal bleeding), colon length, and histological injury scores were analyzed.

    • Main Results:

    • bFGF enema administration significantly reduced clinical scores (p < 0.01).
    • Histological scores of mucosal injury were also significantly improved by bFGF treatment (p < 0.01).
    • No adverse side effects were observed with bFGF administration.

    Conclusions:

    • Intracolonic bFGF enema is clinically safe and effective for treating inflammatory bowel disease.
    • bFGF enema represents a potential novel therapeutic approach for IBD.
    • Further research into bFGF as an IBD therapy is warranted.