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The p300/CBP family: integrating signals with transcription factors and chromatin

N Shiama

    Trends in Cell Biology
    |June 1, 1997
    PubMed

    Insights

    Adenovirus E1a oncoprotein disrupts cell cycle control by inactivating tumor suppressor proteins. Its interaction with p300/CBP proteins is crucial for regulating gene expression and cell differentiation, with implications for cancer development.

    Area of Science:

    • Molecular Biology
    • Virology
    • Cell Biology

    Background:

    • Oncogene products from DNA tumor viruses offer insights into mammalian cell cycle regulation.
    • The adenovirus E1a oncoprotein utilizes distinct protein domains to promote cell growth.

    Purpose of the Study:

    • To investigate the mechanisms by which adenovirus E1a oncoprotein affects cell proliferation.
    • To explore the role of E1a-interacting proteins, specifically p300/CBP, in cellular processes.

    Main Methods:

    • Studies on viral oncoproteins and their interactions with cellular proteins.
    • Analysis of protein domains and their association with proliferation-restraining factors.

    Main Results:

    • Adenovirus E1a oncoprotein physically associates with and inactivates cellular proteins that normally inhibit proliferation.
    • E1a-interacting proteins, p300/CBP, are identified as key regulators of transcription and chromatin.
    • p300/CBP proteins integrate signals for differentiation and coordinate gene expression.

    Conclusions:

    • Adenovirus E1a oncoprotein subverts cell cycle control through interaction with cellular proteins.
    • p300/CBP proteins play a significant role in gene regulation, differentiation, and are implicated in cancer.

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