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Is dynamin really a 'pinchase'?

B Kelly

    Trends in Cell Biology
    |July 1, 1997
    PubMed
    Summary
    This summary is machine-generated.

    Dynamin, a protein crucial for cell biology, is widely believed to sever membrane vesicles. This article questions this "pinchase" dogma, exploring alternative functions for dynamin in cellular processes.

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    Area of Science:

    • Cell Biology
    • Molecular Biology
    • Biochemistry

    Background:

    • The function of the large GTPase dynamin in severing membrane vesicles from donor membranes has been a subject of recent discussion.
    • A prevailing view suggests dynamin acts as a "pinchase," essential for vesicle budding.
    • This perspective is presented as established knowledge in major cell-biology textbooks.

    Purpose of the Study:

    • To critically evaluate the evidence supporting dynamin's role as a "pinchase."
    • To discuss limitations and potential problems with the "pinchase" hypothesis.
    • To explore and present alternative, potentially equally valid, functions of dynamin.

    Main Methods:

    • Review of existing scientific literature on dynamin function.
    • Critical analysis of experimental evidence supporting the "pinchase" model.

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  • Comparative evaluation of alternative functional hypotheses for dynamin.

    • Main Results:

    • The evidence for dynamin acting exclusively as a "pinchase" is not conclusive and may be prematurely accepted as dogma.
    • Certain aspects of the "pinchase" model present theoretical or experimental challenges.
    • Alternative functions for dynamin are identified and supported by existing data, suggesting a broader biological role.

    Conclusions:

    • The role of dynamin as solely a "pinchase" may be an oversimplification.
    • Further research is needed to fully elucidate the diverse functions of dynamin beyond vesicle scission.
    • Recognizing alternative functions is crucial for a comprehensive understanding of dynamin's contribution to cellular processes.