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Updated: Jul 12, 2026
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Analysis of Zebrafish Kidney Development with Time-lapse Imaging Using a Dissecting Microscope Equipped for Optical Sectioning
Published on: April 7, 2016
CITED1 expression in Wilms' tumor and embryonic kidney
Harold N Lovvorn1, Jenifer Westrup, Shaun Opperman
1The Department of Pediatric Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA. harold.lovvorn@vanderbilt.edu
Neoplasia (New York, N.Y.)
|August 22, 2007
Summary
CITED1, a gene regulator, is consistently found in Wilms
Area of Science:
- Developmental Biology
- Pediatric Oncology
- Molecular Biology
Background:
- Wilms' tumors (nephroblastomas) originate from aberrant nephrogenic progenitor cells.
- CITED1 is a transcriptional regulator normally downregulated during kidney development.
- Previous work showed CITED1 expression in nephrogenic progenitors.
Purpose of the Study:
- To investigate the role and localization of CITED1 in Wilms' tumors.
- To determine if CITED1 expression correlates with tumor dissemination.
- To explore CITED1's potential role in Wilms' tumor pathogenesis.
Main Methods:
- Immunohistochemical analysis of CITED1 expression in rat and human Wilms' tumors.
- Comparison of CITED1 subcellular localization in normal kidney versus tumor tissue.
- Correlation of CITED1 expression levels with clinical presentation (disseminated disease).
Main Results:
- CITED1 expression persists in blastemal cells of Wilms' tumors.
- Highest CITED1 levels observed in tumors with disseminated disease.
- CITED1 shows nuclear localization in Wilms' tumor blastema, unlike cytoplasmic localization in normal kidneys.
Conclusions:
- CITED1 is a marker of primitive blastema in Wilms' tumors.
- Persistent expression and altered nuclear localization of CITED1 may contribute to Wilms' tumor initiation.
- CITED1's role in nephrogenic progenitor cell regulation is critical in understanding Wilms' tumorigenesis.
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