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Updated: Jul 12, 2026

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Dicationic ion-pairing agents for the mass spectrometric determination of perchlorate
P Kalyani Martinelango1, Purnendu K Dasgupta
1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
Abstract:
Perchlorate and other hydrophobic ions can be measured with high sensitivity and selectivity by forming a positively charged ion pair with a dicationic agent. A commercially available reagent, 1,6-bis(trimethylammonium)hexane dibromide (Br(N(CH3)3)(CH2)6(N(CH3)3)Br) allows for the determination of perchlorate by electrospray ionization mass spectrometry as the [(N(CH3)3)(CH2)6(N(CH3)3)ClO4]+ ion. Limits of detection (LODs) are better than those previously observed with custom-synthesized dicationic agents. An LOD of 20 ng/L is readily attainable with a single-quadrupole mass spectrometer.
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