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Photoageing: mechanism, prevention and therapy.
1Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118-2394, USA.
The British Journal of Dermatology
|August 23, 2007
Summary
Photoageing, caused by chronic ultraviolet (UV) damage, accelerates skin aging. New treatments and sunscreens offer hope for preventing and reversing these effects, potentially reducing skin cancer risk.
Area of Science:
- Dermatology
- Molecular Biology
- Biochemistry
Background:
- Photoageing, the visible aging of skin due to UV exposure, is a significant concern.
- It results from cumulative UV damage superimposed on intrinsic aging processes.
- Key molecular events include receptor signaling, mitochondrial damage, protein oxidation, and DNA damage responses.
Purpose of the Study:
- To review the mechanisms driving photoageing.
- To highlight current and emerging strategies for prevention and treatment.
- To discuss the potential impact on skin appearance and skin cancer reduction.
Main Methods:
- Review of scientific literature on photoageing mechanisms.
- Analysis of current therapeutic interventions like sunscreens and retinoids.
- Exploration of novel treatment concepts based on UV protective mechanisms.
Main Results:
- Photodamaged skin exhibits changes in epidermal thickness, dermal elastosis, collagen degradation, and increased inflammation.
- Effective sunscreens (UVA/UVB) and treatments like tretinoin are crucial for prevention and reversal.
- Understanding innate UV protection pathways opens avenues for innovative therapies.
Conclusions:
- Photoageing significantly alters skin structure and appearance.
- Advances in sun protection and targeted therapies are improving outcomes.
- Future research promises revolutionary treatments for photoageing and reduced skin cancer incidence.
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