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Updated: Jul 12, 2026
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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
Altered microRNA expression in human heart disease
Sadakatsu Ikeda1, Sek Won Kong, Jun Lu
1Department of Cardiology, Children's Hospital Boston, Boston, MA 02115, USA.
Physiological Genomics
|August 23, 2007
Summary
MicroRNAs regulate gene expression and heart function. This study profiled microRNAs in human heart failure, revealing distinct expression patterns for different heart diseases.
Area of Science:
- Molecular Biology
- Genetics
- Cardiology
Background:
- MicroRNAs (miRNAs) are key gene expression regulators increasingly linked to cardiac function.
- Previous genome-wide miRNA profiling in human heart failure was lacking.
Purpose of the Study:
- To perform genome-wide miRNA profiling in human heart failure.
- To identify distinct miRNA expression signatures in different heart disease types.
Main Methods:
- Measured expression of 428 miRNAs in 67 human left ventricular samples.
- Included control, ischemic cardiomyopathy (ICM), dilated cardiomyopathy (DCM), and aortic stenosis (AS) groups.
- Utilized ANOVA, Dunnett's post hoc test, and false discovery rate for statistical analysis.
Main Results:
- 87 of 428 miRNAs were detected; 43 showed differential expression across disease groups.
- Supervised clustering accurately grouped samples by clinical diagnosis based on miRNA profiles.
- A miRNA-based classifier achieved 69% accuracy in predicting clinical diagnosis (P < 0.001).
Conclusions:
- Altered miRNA expression is common in heart disease.
- Distinct heart diseases exhibit unique miRNA expression profiles.
- These findings provide a foundation for investigating miRNA roles in heart disease pathogenesis.
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