Lack of effect of focally administered prostaglandins on electrically kindled seizure activity

Several previous studies have demonstrated increased synthesis of cerebral prostaglandins (PGs) following convulsive activity. In addition, it has been proposed that endogenous prostanoids have anticonvulsive properties and may act to attenuate or limit seizure activity in vivo. In this study we have used focal injections of prostaglandins (PGs) to examine their potential modulatory effects on electrically kindled seizure activity. We report that the intra-amygdaloid administration of PGD2, PGE2 or PGF2a, (1-10 micrograms) showed no significant effects on any of the kindled seizure parameters studied. The highest dose of PGF2a was ineffective at all pretreatment times between 2-30 mins. Our data is inconsistent with the view that PGs exert protective effects against seizure activity, at least within the amygdala against electrically kindled seizures.