Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 12, 2026

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

Peptide-based therapy in lupus: promising data.

Fanny Monneaux1, Sylviane Muller

  • 1Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France.

Advances in Experimental Medicine and Biology
|August 24, 2007
PubMed
Summary

Systemic lupus erythematosus (SLE) treatments cause non-specific immune suppression. Alternative therapies focus on specific T cell targeting using autoantigen-derived peptides to avoid these side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peptide-mediated inhibition of aberrant chaperone-mediated autophagy in pericytes prevents glioblastoma progression through MAPT/tau secretion.

Autophagy·2026
Same author

Autoimmunity, diet and autophagy.

Autoimmunity reviews·2026
Same author

Pathophysiological effects of long COVID-19 (auto)antibodies on fertility.

Journal of autoimmunity·2025
Same author

Long COVID-19 autoantibodies and their potential effect on fertility.

Frontiers in immunology·2025
Same author

Autophagy in myositis, a dysregulated pathway, and a target for therapy.

Autoimmunity reviews·2025
Same author

Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice.

ImmunoTargets and therapy·2025

Area of Science:

  • Immunology
  • Rheumatology
  • Inflammatory Diseases

Background:

  • Systemic lupus erythematosus (SLE) is a chronic, multisystem inflammatory disease.
  • Current treatments rely on broad immunosuppressants like corticosteroids and cyclophosphamide.
  • These therapies lead to non-specific immune suppression and associated side effects.

Purpose of the Study:

  • To explore alternative therapeutic strategies for SLE.
  • To develop treatments that avoid the side effects of current immunosuppressants.
  • To investigate targeted T cell therapies using autoantigen-derived peptides.

Main Methods:

  • Identification of major T cell epitopes from autoantigens relevant to SLE.
  • Design and synthesis of peptide-based immunomodulators.
  • Preclinical evaluation of peptide efficacy and safety in SLE models (details not provided in abstract).

Main Results:

  • Autoantigen-derived peptides encompassing major epitopes were identified (details not provided in abstract).
  • These peptides show potential for specific T cell targeting (details not provided in abstract).
  • The approach aims to mitigate non-specific immunosuppression seen with current SLE treatments.

Conclusions:

  • Targeted T cell modulation using autoantigen-derived peptides represents a promising alternative therapeutic strategy for SLE.
  • This approach may offer a way to manage SLE while minimizing the adverse effects of conventional immunosuppressive drugs.
  • Further research into peptide-based therapies could lead to more effective and safer treatments for SLE patients.

Related Experiment Videos

Last Updated: Jul 12, 2026

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
10:18

Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023