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Updated: Jul 12, 2026

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Planar optofluidic chip for single particle detection, manipulation, and analysis.

Dongliang Yin¹, Evan J Lunt, Mikhail I Rudenko

¹School of Engineering, University of CA Santa Cruz, CA 95064, USA.

|August 24, 2007

Summary

This study introduces a fully planar optofluidic chip for single particle analysis. The platform enables electrical control and optical detection of fluorescent liposomes for concentration and dynamic property determination.

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Area of Science:

Optofluidics
Nanotechnology
Biophysics

Background:

Integrated optofluidic platforms are crucial for miniaturized analytical devices.
Existing platforms often lack full planarity, limiting integration and scalability.
Precise control and detection of single particles are essential for advanced diagnostics.

Purpose of the Study:

To develop a fully planar integrated optofluidic platform for single particle detection, manipulation, and analysis.
To demonstrate the platform's capability using fluorescently labeled liposomes.
To enable on-chip determination of particle concentration and dynamic properties.

Main Methods:

Integration of liquid-core and solid-core optical waveguides for light and fluid guiding.
Creation of sub-picoliter excitation volumes for high-sensitivity detection.

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Last Updated: Jul 12, 2026

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

A Protocol for Real-time 3D Single Particle Tracking

A Protocol for Real-time 3D Single Particle Tracking

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Electrical control of particle motion and fluorescence correlation spectroscopy (FCS) for analysis.

Main Results:

Successful demonstration of a fully planar optofluidic chip.
Electrical manipulation and optical detection of single fluorescent liposomes achieved.
Accurate determination of liposome concentration, diffusion coefficient, and velocity using FCS.

Conclusions:

The developed platform offers a novel approach to on-chip single particle analysis.
This fully planar design facilitates integration with semiconductor technologies.
The technology holds potential for developing new classes of portable optofluidic instruments.