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Human heart beta-adrenoceptors: beta1-adrenoceptor diversification through 'affinity states' and polymorphism

P Molenaar1, L Chen, A B T Semmler

  • 1Department of Medicine, The University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia. p.molenaar@uq.edu.au

Clinical and Experimental Pharmacology & Physiology
|August 24, 2007
PubMed
Summary

Beta-adrenoceptors in the heart activate signaling pathways for contraction and relaxation. Studies reveal two affinity states of the beta(1)-adrenoceptor and their varying response to beta-blockers, influencing heart failure treatment outcomes.

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