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Updated: Jul 12, 2026
The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
Published on: August 18, 2011
[Analgesic effect of interleukin-2 in mouse models of spared nerve injury]
Shan Liu1, Lin Shi, Jun-Yang Wang
1Department of Immunology and Microbiology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. llllllandsss@sohu.com
Objective:
To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).
Method:
IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.
Results:
IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.
Conclusions:
IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.
