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Magnetic resonance-compatible-spirometry: principle, technical evaluation and application.

M Eichinger1, M Puderbach, H-J Smith

  • 1Department of Radiology (E010), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. m.eichinger@dkfz.de

The European Respiratory Journal
|August 24, 2007
PubMed
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This study demonstrates that magnetic resonance-compatible spirometry is feasible, safe, and reliable for measuring lung function. Magnetic resonance imaging settings have minimal impact on spirometry results, showing good correlation with dynamic imaging measurements.

Area of Science:

  • Medical Imaging
  • Pulmonary Function Testing
  • Biomedical Engineering

Background:

  • Accurate lung function assessment is crucial for diagnosing and managing respiratory diseases.
  • Traditional spirometry cannot be performed simultaneously with magnetic resonance (MR) imaging.
  • Developing a magnetic resonance-compatible spirometer (MRc-spirometer) is essential for integrated respiratory function assessment during MR scans.

Purpose of the Study:

  • To evaluate the feasibility, accuracy, and reliability of a novel MRc-spirometer.
  • To assess the influence of body posture, MR settings, and image acquisition on lung function measurements.
  • To compare lung function data from the MRc-spirometer with dynamic MR imaging (dMRI) measurements.

Main Methods:

  • A commercial spirometer was adapted to be magnetic resonance-compatible (MRc-spirometer).

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  • Feasibility and accuracy were assessed using flow-generator measurements and forced expiratory maneuvers in 34 healthy adults.
  • Simultaneous measurements of lung function and dMRI were performed, with analysis including paired t-tests and Bland-Altman plots.

    • Main Results:

    • The MRc-spirometer demonstrated high accuracy, with mean differences of 0.004 L for forced expiratory volume in one second (FEV(1)) and 0.018 L for forced vital capacity (FVC) compared to a reference.
    • FEV(1) measurements showed a strong correlation (r = 0.72) with dMRI-derived changes in apico-diaphragmatic distance.
    • A minor influence of MR system settings on FEV(1) was observed in subgroup analysis.

    Conclusions:

    • Magnetic resonance-compatible spirometry is a feasible, reliable, and safe method for simultaneous lung function measurement during MR imaging.
    • MR system settings exert only a small influence on spirometry outcomes.
    • dMRI measurements correlate well with simultaneously acquired lung function parameters, enabling integrated cardiorespiratory assessments.