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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
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Changes in urinary bladder smooth muscle function in response to colonic inflammation.

R Noronha1, H Akbarali, A Malykhina

  • 1Oklahoma Center for Neurosciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

American Journal of Physiology. Renal Physiology
|August 24, 2007
PubMed
Summary

Acute colitis temporarily impairs bladder muscle contractility, potentially through nerve changes. These bladder function alterations are reversible once colon inflammation resolves, suggesting visceral cross-talk in inflammatory conditions.

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Area of Science:

  • Urology
  • Gastroenterology
  • Physiology

Background:

  • Visceral cross-talk is implicated in conditions like irritable bowel syndrome and interstitial cystitis.
  • Understanding colon-bladder interactions is crucial for managing complex symptomatology.

Purpose of the Study:

  • To investigate the short- and long-term effects of acute colitis on bladder detrusor muscle contractility.
  • To determine if colon inflammation directly alters bladder smooth muscle function.

Main Methods:

  • Acute colitis was induced in male rats using trinitrobenzenesulfonic acid (TNBS) enema.
  • Bladder detrusor muscle contractility was assessed at 3, 15, and 30 days post-induction via electrical field stimulation (EFS) and carbachol (CCh).
  • Colitis severity was confirmed through morphology, histology, and myeloperoxidase activity.

Main Results:

  • At day 3, during active colitis, bladder detrusor muscle showed normal morphology but altered contractility in response to EFS and CCh, not KCl.
  • Contractility changes were linked to alterations in cholinergic innervation.
  • By days 15 and 30, following colitis recovery, bladder contractility returned to control levels.

Conclusions:

  • Transient colonic inflammation transiently attenuates bladder detrusor muscle contraction amplitude.
  • These effects are, in part, mediated by changes in cholinergic innervation.
  • The observed bladder dysfunction is reversible upon resolution of colonic inflammation.