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ACE inhibitor fetopathy and hypocalvaria: the kidney-skull connection
Teratology
|November 11, 1991
Abstract:
Two cases of angiotensin converting enzyme inhibitor fetopathy with renal tubular dysgenesis and severely underdeveloped calvarial bone are described. Six additional, unexposed cases of hypocalvaria are described, and possible links between calvarial development and fetal hypotension and/or chronic hypoxia are explored.
Insights
Angiotensin converting enzyme inhibitor fetopathy can cause severe calvarial bone underdevelopment and renal tubular dysgenesis. This study explores links between fetal hypotension, chronic hypoxia, and impaired calvarial bone development.
Area of Science:
- Perinatology
- Developmental Biology
- Pharmacology
Background:
- Angiotensin converting enzyme (ACE) inhibitors are prescribed during pregnancy.
- ACE inhibitor fetopathy is a known teratogenic condition.
- Calvarial bone development is sensitive to fetal environment.