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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: Jul 12, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Nanoparticles in drug delivery and environmental exposure: same size, same risks?

Paul J A Borm1, Detlef Müller-Schulte

  • 1Zuyd University, Centre of Expertise in Life Sciences, Nieuw Eyckholt 300, An Heerlen, The Netherlands. p.borm@hszuyd.nl

Nanomedicine (London, England)
|August 25, 2007
PubMed
Summary

Engineered nanoparticles offer promise for nanomedicine, but their toxicological effects, similar to combustion nanoparticles, require careful study. Understanding common nanoparticle mechanisms is key for safe development and application.

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Last Updated: Jul 12, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison
07:08

Nanoparticle Tracking Analysis of Gold Nanoparticles in Aqueous Media through an Inter-Laboratory Comparison

Published on: October 20, 2020

Area of Science:

  • Nanomedicine
  • Toxicology
  • Materials Science

Background:

  • Engineered nanoparticles are crucial for drug delivery and imaging in nanomedicine.
  • Various carrier systems like liposomes, dendrimers, and polymer carriers have been developed.
  • Toxicological concerns arise from nanoparticle exposure, mirroring effects seen with combustion-derived nanoparticles.

Purpose of the Study:

  • To identify common mechanisms underlying nanoparticle action.
  • To facilitate cross-talk and knowledge sharing between different fields of nanoparticle research.
  • To address toxicological challenges in the development of nanomedicines.

Main Methods:

  • Review of existing literature on engineered and combustion-derived nanoparticles.
  • Analysis of toxicological data, including oxidative stress and inflammation.
  • Comparison of internalization and translocation mechanisms across different nanoparticle types.

Main Results:

  • Engineered nanoparticles share toxicological pathways with combustion-derived nanoparticles.
  • Oxidative stress and inflammation are key mediators of nanoparticle toxicity.
  • Mechanisms of internalization and translocation are critical for understanding nanoparticle effects.

Conclusions:

  • A unified understanding of nanoparticle action is essential for advancing nanomedicine safely.
  • Addressing shared toxicological concepts can accelerate the development of novel nanotherapeutics.
  • Further research into common nanoparticle mechanisms will enable better risk assessment and therapeutic design.