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FDG-PET in T-cell and NK-cell neoplasms
1Department of Hematology & Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Summary
18-Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is useful for T-cell and natural killer (NK)-cell neoplasms, detecting lesions in most patients. However, FDG-PET uptake is limited in cutaneous lesions and bone marrow involvement.
Area of Science:
- Oncology
- Nuclear Medicine
- Hematology
Background:
- (18)Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is valuable in managing malignant lymphoma.
- Limited studies have investigated FDG-PET utility in T-cell and natural killer (NK)-cell neoplasms.
Purpose of the Study:
- To evaluate the effectiveness of pretreatment FDG-PET scans in patients with T/NK-cell neoplasms.
- To determine FDG-PET avidity across different histological subtypes of T/NK-cell neoplasms.
Main Methods:
- Retrospective analysis of pretreatment FDG-PET scans in 41 patients with T/NK-cell neoplasms (WHO classification).
- Included subtypes: PTCLu (n=11), ENKL (n=8), C-ALCL (n=5), AILT (n=4).
Main Results:
- FDG-PET detected lymphoma in 36/41 patients (88% overall positive rate).
- High positive rates observed in PTCLu (91%), ENKL (100%), and AILT (100%).
- Lower positive rate for C-ALCL (60%), with FDG-PET ineffective for non-tumorous cutaneous lesions and bone marrow involvement (20% positive rate).
Conclusions:
- T/NK-cell neoplasms are generally FDG-avid.
- FDG-PET utility is limited for cutaneous lesions and bone marrow involvement in these neoplasms.
