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Fluorodeoxyglucose-PET in Melanoma and Soft-Tissue Sarcoma: Current Applications, Challenges, and Future Directions
Sambit Sagar1, Dikhra Khan1, Nivedita Kundu2
1Department of Nuclear Medicine, All India Institute of Medical Sciences (AIIMS CAPFIMS), New Delhi, India.
Fluorodeoxyglucose PET/CT is crucial for managing melanoma and soft-tissue sarcoma, aiding in staging and treatment assessment. Advanced techniques like radiomics and AI are enhancing its role in personalized cancer care.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Fluorodeoxyglucose Positron Emission Tomography/computed tomography (FDG PET/CT) is integral to cancer management.
- Melanoma and soft-tissue sarcoma require precise staging and response assessment for effective treatment.
Purpose of the Study:
- To highlight the central role of FDG PET/CT in managing melanoma and soft-tissue sarcoma.
- To discuss its applications in staging, response assessment, and prognostication.
- To explore emerging roles in precision oncology.
Main Methods:
- Comprehensive metabolic imaging using FDG PET/CT.
- Utilizing quantitative PET parameters for prognostic evaluation.
- Investigating emerging applications like radiomics and artificial intelligence.
Main Results:
- FDG PET/CT improves detection of distant disease and guides clinical decisions, especially in advanced stages.
- Quantitative PET parameters offer enhanced prognostic value.
- Radiomics and AI are poised to further refine its use in precision oncology.
Conclusions:
- FDG PET/CT is a vital tool for melanoma and soft-tissue sarcoma management.
- Careful interpretation is necessary to address limitations such as false positives and atypical immunotherapy responses.
- Its role is evolving towards personalized cancer treatment strategies.
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