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Related Experiment Video

Updated: Jul 12, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

Natural killer cells and CD4+ T-cells modulate collateral artery development.

V van Weel¹, R E M Toes, L Seghers

¹Gaubius Laboratory, TNO-QOL, P.O. Box 2215, 2301CE Leiden, The Netherlands.

Arteriosclerosis, Thrombosis, and Vascular Biology

|August 25, 2007

Summary

Natural Killer (NK) cells and CD4+ T-cells are crucial for collateral circulation (arteriogenesis) in hindlimb ischemia. Modulating lymphocyte activity may offer new treatments for ischemic diseases.

Related Experiment Videos

Last Updated: Jul 12, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

Area of Science:

Immunology
Vascular Biology
Cardiovascular Research

Background:

Collateral circulation (arteriogenesis) is vital for patients with arterial obstructive disease.
The immune system's role in arteriogenesis is increasingly recognized.
Lymphocytes are implicated in regulating blood vessel formation.

Purpose of the Study:

To investigate the specific roles of lymphocytes, including Natural Killer (NK) cells and T-cells, in arteriogenesis.
To elucidate the mechanisms by which lymphocytes influence collateral vessel development in a murine model of hindlimb ischemia.

Main Methods:

Utilized a murine model of hindlimb ischemia.
Employing lymphocyte depletion strategies using antibodies against NK1.1 and CD4.
Investigated NK-cell-deficient and MHC-class-II-deficient mice.
Compared arteriogenesis in different mouse strains (C57BL/6 and BALB/c).

Main Results:

Lymphocytes, including NK cells and CD4+ T-cells, infiltrate collateral vessel walls.
Arteriogenesis was significantly impaired in mice lacking NK cells or CD4+ T-cells.
NK cells, not NK T (NKT) cells, were found to be involved.
Mice lacking both NK and CD4+ T-cells showed profound impairment in collateral growth.
Strain-dependent differences in arteriogenesis were observed between BALB/c and C57BL/6 mice.

Conclusions:

Both NK cells and CD4+ T-cells play a significant modulatory role in arteriogenesis.
Targeting lymphocyte activation presents a potential therapeutic strategy for treating ischemic diseases.
Understanding lymphocyte involvement in collateral circulation is key for developing novel treatments.