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Related Experiment Videos

Tumour vascularization: sprouting angiogenesis and beyond.

Femke Hillen1, Arjan W Griffioen

  • 1Angiogenesis Laboratory, Research Institute for Growth and Development (GROW), Department of Pathology, Maastricht University & University Hospital Maastricht, P.O. Box 5800, 6202, AZ Maastricht, The Netherlands.

Cancer Metastasis Reviews
|August 25, 2007
PubMed
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Tumour vascularisation involves more than just new vessel growth. Understanding intussusceptive angiogenesis, vessel co-option, and vasculogenic mimicry is key for effective cancer therapy strategies.

Area of Science:

  • Tumour biology
  • Vascular biology
  • Cancer research

Background:

  • Tumour angiogenesis, the growth of new blood vessels in tumours, has long been studied.
  • For decades, sprouting angiogenesis was considered the sole mechanism of tumour vascularisation.
  • Recent discoveries reveal additional complex mechanisms contributing to tumour growth and vascularisation.

Purpose of the Study:

  • To review the diverse mechanisms of tumour vascularisation beyond traditional angiogenesis.
  • To highlight the roles of intussusceptive angiogenesis, endothelial progenitor cell recruitment, vessel co-option, vasculogenic mimicry, and lymphangiogenesis in tumour growth.
  • To discuss the implications of these findings for developing novel cancer therapies.

Main Methods:

  • Literature review of recent studies on tumour vascularisation mechanisms.

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  • Analysis of the contribution of newly identified processes to tumour growth.
  • Evaluation of potential therapeutic interventions targeting these mechanisms.

    • Main Results:

    • Tumour vascularisation is a multifaceted process involving multiple pathways.
    • Intussusceptive angiogenesis, endothelial progenitor cell recruitment, vessel co-option, vasculogenic mimicry, and lymphangiogenesis significantly contribute to tumour growth.
    • These complex mechanisms necessitate a broader approach to anti-tumour strategies.

    Conclusions:

    • Future anti-vascular therapies require a multimodal approach.
    • Combining anti-angiogenic, anti-vasculogenic mimicry, and anti-lymphangiogenic strategies may offer enhanced efficacy.
    • A comprehensive understanding of tumour vascularisation is crucial for advancing cancer treatment.