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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

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Related Experiment Video

Updated: Jul 12, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

[Epilepsy and Sabril].

F Depasse1

  • 1Service d'Ophtalmologie, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles. fanny.depasse@erasme.ulb.ac.be

Bulletin De La Societe Belge D'Ophtalmologie
|August 28, 2007
PubMed
Summary

This review examines Sabril

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Neuroscience

Context:

  • Sabril (vigabatrin) is an antiepileptic drug.
  • Ophthalmologic side effects are a known concern with Sabril treatment.
  • Understanding these effects is crucial for patient management.

Purpose:

  • To provide a literature overview of Sabril's secondary ophthalmologic effects.
  • To review visual field loss associated with Sabril.
  • To propose follow-up algorithms for patients on Sabril.

Summary:

  • The article reviews visual field loss linked to Sabril treatment, exploring epidemiological and physiopathological factors.
  • It examines the relationship between electrophysiology and physiopathology in these cases.
  • Two follow-up algorithms, for adults and children, are presented.

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Planarian as an Animal Model for Experimental Acute Seizure
08:29

Planarian as an Animal Model for Experimental Acute Seizure

Published on: February 14, 2025

Related Experiment Videos

Last Updated: Jul 12, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Planarian as an Animal Model for Experimental Acute Seizure
08:29

Planarian as an Animal Model for Experimental Acute Seizure

Published on: February 14, 2025

Impact:

  • Informs clinicians about Sabril-induced visual field defects.
  • Provides practical guidance for ophthalmologic monitoring.
  • Aids in the safe and effective use of Sabril in epilepsy management.