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Clot waveform analysis: Where do we stand in 2017?

P O Sevenet1, F Depasse1

  • 1Diagnostica Stago S.A.S, Asnières sur Seine, France.

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|September 7, 2017
PubMed
Summary

Clot waveform analysis (CWA) offers valuable insights beyond clotting time in coagulation assays. This inexpensive, rapid technique aids in diagnosing and managing various bleeding disorders and thrombotic conditions.

Keywords:
activated partial thromboplastin timebiphasic waveformclot waveformdisseminated intravascular coagulationhaemophiliatransmittance

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Biomedical Engineering

Background:

  • Global coagulation assays like activated partial thromboplastin time and prothrombin time yield more data than just clotting time.
  • Optical waveform analysis during these assays provides significant information about the plasma's coagulation status.

Purpose of the Study:

  • To review current knowledge on clot waveform analysis (CWA).
  • To explore research data, clinical applications, and future trends of CWA.

Main Methods:

  • Extensive literature review of studies on clot waveform analysis (CWA).

Main Results:

  • CWA has demonstrated utility in diagnosing and managing hemophilia A, disseminated intravascular coagulation, sepsis, lupus anticoagulant, and for anticoagulant monitoring.
  • CWA is inexpensive, rapid, and readily available on optical detection coagulation analyzers.

Conclusions:

  • Clot waveform analysis (CWA) significantly enhances patient management by providing comprehensive coagulation insights.
  • CWA represents a valuable, accessible tool with broad clinical potential in hemostasis and thrombosis.