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09:48
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Insulin resistance in adolescents
Ann M Rodden1, Vanessa A Diaz, Arch G Mainous
1Medical University of South Carolina, Department of Family Medicine, Charleston, South Carolina, USA. rodden@musc.edu
The Journal of Pediatrics
|August 28, 2007
Summary
Adolescents with a BMI at the 75th percentile or higher show increased odds of insulin resistance. This finding highlights previously unrecognized risks in adolescents with elevated body mass index (BMI).
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Public Health
Background:
- Insulin resistance is a growing concern in adolescent health.
- Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) is a key marker for insulin resistance.
- Understanding the link between Body Mass Index (BMI) and HOMA-IR in adolescents is crucial.
Purpose of the Study:
- To examine the association between various Body Mass Index (BMI) ranges and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) in adolescents.
- To identify specific BMI percentiles linked to elevated insulin resistance.
- To inform public health strategies for adolescent metabolic health.
Main Methods:
- Cross-sectional analysis of 1837 non-diabetic, non-pregnant adolescents (ages 12-19).
- Data sourced from the National Health and Nutrition Examination Survey (1999-2002).
- Insulin resistance defined as HOMA-IR > 3.16.
Main Results:
- A Body Mass Index (BMI) at or above the 75th percentile was significantly associated with high HOMA-IR levels.
- Increasing BMI percentile correlated with increased odds of high HOMA-IR.
- Odds ratios for high HOMA-IR were 4.277 (75th-84.9th percentile), 4.299 (85th-94.9th percentile), and 17.907 (≥95th percentile).
Conclusions:
- Adolescents with BMI percentile 75-84.9, representing ~1.2 million US youth, exhibit higher HOMA-IR levels.
- These findings identify a previously unrecognized risk group for insulin resistance.
- Early identification and intervention for elevated BMI in adolescents are critical for metabolic health.
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