Related Experiment Video
Updated: Jul 12, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
Regression simulation of the dependence of forced expiratory tracheal noises duration on human respiratory system
Vladimir I Korenbaum1, Irina A Pochekutova
1V.I. Il'ichev Pacific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences, 43 Baltiyskaya Street, Vladivostok 690041, Russia. v-kor@poi.dvo.ru
Background:
Estimating the duration of forced exhalation tracheal noises shows promise for recognizing bronchial obstruction.
Objective:
Experimental simulation of an influence of biomechanical parameters on the duration of normal forced exhalation tracheal noises.
Method And Materials:
Thirty-two healthy non-smoking men aged 16-22 years were examined. The duration of noises, the parameters of computer spirometry, and the maximum static expiratory pressure are recorded. These data were analyzed by means of multiple linear regression simulation for logarithms of the elements of the proportionality relation obtained with the use of a one-component biomechanical model of forced exhalation and a linearized approximation of flow-volume curve.
Results:
Dependence between duration of the forced expiratory noises recorded on human trachea and the product of forced volume capacity (in power of 1.05 +/- 0.27), maximum static expiratory pressure (in power of 0.46 +/- 0.23), equivalent expiratory resistance in the stage of functional expiratory stenosis (in power of 0.72 +/- 0.15 in healthy is an estimate of the equivalent expiratory resistance of human bronchial tree in the functional expiratory stenosis phase, whereas in patients with bronchial obstruction it is supposed to take into account an excess of noise generation time compared with the time predicted from normal individual value of this resistance.
Related Concept Videos
Respiratory Capacities
One key metric is the Inspiratory Capacity (IC), which represents the maximum amount of air that can be inhaled with full effort. IC is calculated by summing the tidal volume and inspiratory reserve volume, typically ranging from 2.4 to 3.6 liters.
The Functional Residual Capacity (FRC) represents the air in the...
Mechanism of Breathing II: Expiration
Expiration, or exhaling, is a complex physiological process that begins as the inspiratory muscles begin to relax. This relaxation triggers a series of events that epitomize the efficiency of the respiratory system.
Mechanism of Expiration:
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Respiratory Volumes and Capacities I
Respiratory Volumes and Capacities

