Related Experiment Video
Updated: Jul 12, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity
Huang Tang1, Xiao-Dong Wang, Yong-Biao Wei
1School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Abstract:
A series of novel oxoisoaporphine alkaloid derivatives, 9-aminoalkanamido-1-azabenzanthrone (general formula Ar-NHCO(CH(2))(n)NR(2), Ar=1-azabenzanthrone, n=1, 2 or 3), had been synthesized. Compared with 1-azabenzanthrone, the derivatives had significantly higher DNA binding affinity with calf thymus DNA, and higher potent cytotoxicity against different tumor cell lines. The cytotoxicity and the structure-activity relationship of the prepared compounds were studied. The derivatives with two methylene groups (n=2), and piperidine or ethanolamine functional group in the side chain exhibited highest DNA binding affinity and cytotoxicity.
More Related Videos
Related Concept Videos
Opioid Receptors: Overview
Inhibitors of Bacterial DNA Synthesis
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Antiviral Nucleoside Inhibitors
Inhibitors of Viral Protein Synthesis

