Related Experiment Video
Updated: Jul 12, 2026
07:56
Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
Published on: November 16, 2018
[Using stromal stem cells for the periodontal tissue regeneration and their interaction with tissue microenvironment]
Morfologiia (Saint Petersburg, Russia)
|August 29, 2007
Summary
Stromal stem cells (SSC) show promise for periodontal tissue regeneration by stimulating cell growth and differentiation. Their interaction with the local environment is key to controlling cellular functions during healing.
Area of Science:
- Periodontology
- Stem Cell Biology
- Tissue Engineering
Context:
- Periodontal disease leads to significant tissue loss.
- Current treatments have limitations in regenerating complex periodontal structures.
- Stem cells offer a novel therapeutic avenue for periodontal regeneration.
Purpose:
- To review the historical progression of periodontal regeneration concepts.
- To explore the potential of stromal stem cells (SSC) in periodontal regeneration.
- To analyze the behavior and interactions of SSC in periodontal defects.
Summary:
- This review traces the evolution of periodontal regeneration strategies, from cellular repopulation to the use of stromal stem cells (SSC).
- It details the effects of SSC from various sources (embryonic, bone marrow, adipose) and their immunophenotype changes during culture.
- The analysis includes SSC proliferation and differentiation in periodontal defects, highlighting the role of cell receptors, adhesion, and communication in regeneration.
Impact:
- Provides a comprehensive overview of SSC applications in periodontal regeneration.
- Identifies key cellular mechanisms governing SSC-mediated periodontal healing.
- Informs future research and clinical strategies for advanced periodontal tissue engineering.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
01:19Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...