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Human DNA topoisomerase IB: structure and functions

Erica Cretaio1, Luca Pattarello, Yari Fontebasso

  • 1Department of Biology, University of Padova, Padova, Italy.

The Italian Journal of Biochemistry
|August 29, 2007
PubMed

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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