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Updated: Jul 12, 2026

Synthesis and Calibration of Phosphorescent Nanoprobes for Oxygen Imaging in Biological Systems
Published on: March 3, 2010
A new chemiluminescence probe for singlet oxygen based on tetrathiafulvalene-anthracene dyad capable of performing
Xiaoping Zheng1, Shuna Sun, Deqing Zhang
1Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Abstract:
A new tetrathiafulvalene-anthracene dyad 1 with two "tetraethylene glycol" units was synthesized and characterized. Strong chemiluminescence was observed upon reaction of dyad 1 with singlet oxygen (1O2), and this reaction shows fairly good selectivity toward 1O2 over other reactive oxygen species. Due to the introduction of two hydrophilic "tetraethylene glycol" units, the detection of 1O2 with dyad 1 can be performed in alcohol/water solution, which is relatively a mild medium when compared with water/tetrahydrofuran solution required by other tetrathiafulvalene-anthracene dyads. Dyad 1 may have a wider use for detection of 1O2 in biological systems.
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