[Radiation-induced human osteogenic sarcoma]

The authors studied clinically, roentgenologically and morphologically 8 patients with radiation osteogenic bone sarcomas which the patients developed 9 to 24 years (15 years, on the average) after distant gamma therapy at total local doses from 35 to 111 Gy (average 63 Gy) for primary skeletogenic and non-skeletogenic tumors when the bone was in the zone of irradiation. Radiation osteogenic sarcomas developed when the women or patients at early age were irradiated. Osteosclerotic (3), osteoblastic (2), osteoid (1), chondroblastic (2) forms of osteogenic sarcoma were identified. Necrotic and regeneratory bone changes preceding tumour growth may be found that alter the roentgenomorphological correlations.