Related Experiment Video

Updated: Jun 24, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

A live attenuated human rotavirus vaccine

David I Bernstein1

  • 1Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio 45229, USA. David.Bernstein@cchmc.org

Drugs of Today (Barcelona, Spain : 1998)
|August 29, 2007
PubMed

Insights

Rotarix is a safe and effective live oral rotavirus vaccine for children, offering 85-100% efficacy against severe gastroenteritis. This vaccine, administered in two doses, protects against common rotavirus serotypes worldwide.

Area of Science:

  • Pediatrics
  • Vaccinology
  • Virology

Background:

  • Rotavirus infections are a primary cause of severe gastroenteritis in young children globally.
  • Development of effective vaccines is crucial for reducing childhood morbidity and mortality.

Purpose of the Study:

  • To review the development and clinical evaluation of Rotarix, a live oral rotavirus vaccine.
  • To summarize the safety and efficacy data from large-scale clinical trials.

Main Methods:

  • Development of Rotarix involved attenuation of a wild-type human rotavirus strain (89-12, G1P[8]) through multiple tissue culture passages.
  • Extensive safety and efficacy trials were conducted, involving over 100,000 children worldwide.

Main Results:

  • Rotarix demonstrated a favorable safety profile, with no association with intussusception.
  • The vaccine is highly immunogenic and provides 85-100% efficacy against severe rotavirus gastroenteritis and hospitalization.
  • Protection extends to the most common circulating human rotavirus serotypes.

Conclusions:

  • Rotarix is a safe and effective vaccine for preventing rotavirus gastroenteritis in children.
  • The vaccine is globally available and recommended as a two-dose oral regimen starting from 6 weeks of age.

More Related Videos

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators08:01

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Published on: January 19, 2024

Related Concept Videos

Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...